Microsoft .net Desktop Runtime %28x64%29 8.0x 'link'

: This architecture designator means the runtime is built for 64-bit processors. It enables applications to utilize more than 4GB of RAM and leverages modern CPU processing power.

For the typical Windows user who just needs to run an application, is required. You do not need the SDK, and you do not need ASP.NET Core Runtime unless the application specifically mentions it.